Can Calculus Help Tuberculosis Treatment?

The St Andrews group’s most recent paper has been published as a perspective piece in the International Journal of Tuberculosis and Lung Disease.The collaboration between the Schools of Medicine, Applied Mathematics and Computer Science provides an overview of the different types of model that can be applied to tuberculosis clinical trials.  Importantly, it provides a new insight on mechanistic models that can explore the interaction between pathogens, immune samples and the local environment including antibiotic concentrations.  Tuberculosis is still one of the top 10 causes of death worldwide, this approach could allow patient level simulations and, ultimately, open the prospect of conducting a virtual clinical trial and help us choose between potential new regimens to test.