Dr. Francis Mhimbira

Dr. Francis Mhimbira is an epidemiologist and a senior research scientist at Ifakara Health Institute (IHI, www.ihi.or.tz). He joined IHI since 2012 working with a TB research group conducting TB epidemiological, diagnostic and clinical trials (drugs and vaccines). He has experience in conducting phase II and phase III TB drug clinical trials. He is currently leading the preparation and conduct of PanACEA related studies at Ifakara Health Institute. Dr. Francis has other research interests which include implementation studies on TB case finding and diagnostic studies.

Dr. Francis received his medical degree from University of Dar es Salaam, Tanzania, a Masters’ degree in Epidemiology from University of Melbourne, Australia and a PhD in Epidemiology from University of Basel, Switzerland.

Dr. Celso Khosa

Celso Khosa is the scientific director of Centro de Investigação e Treino em Saúde da Polana Caniço (CISPOC), Instituto Nacional de Saúde Mozambique (INS) since 2018 and he is responsible for the daily activities of PanACEA II in Mozambique.

Dr. Khosa has been a medical doctor and researcher at INS-CISPOC since 2013, leading the TB research program, implementing observational studies and clinical trials in TB therapeutics and diagnostics in adult and paediatric population. He is a last year PhD candidate in Medical Research / International Health at the University of Munich. Dr. Khosa is currently the Principal Investigator in several TB studies, including clinical trials for new drugs in TB and HIV treatment.

His main research interest includes tuberculosis, HIV and Comorbidities associated with HIV.

Dr Julia Dreisbach

Dr. Julia Dreisbach, a veterinary doctor, led the preclinical development of BTZ-043 and now acts as clinical project manager in the BTZ-043 Multiple Ascending Dose Study in Patients.

She coordinates in parallel all non-clinical activities like for example long term toxicity studies in animals, cold- and radiolabeled ADME studies in animals and the development of a suitable drug formulation for BTZ-043

Dr Susanne Schultz

Dr Susanne Schultz studied medicine at the University of Hamburg and is a qualified consultant for general medicine and emergency medicine. From 2007 until 2016 she was living and working as a general practitioner in the UK, the Netherlands and Turkey and completed an MSc in Clinical Trial Management at the Beuth Technical University, Berlin. During these years Dr Schultz supported charities in Kenya as a clinician and medical advisor. She joined the University of Munich in 2017 as clinical investigator and clinical trial coordinator, managing a multi-center trial in the Department for General and Family Medicine. In 2018 she took on a position as sponsor medical expert in the Division of Infectious Diseases and Tropical Medicine, where Dr Schultz is currently working several Phase II TB studies within PanACEA and other projects in Africa.

Larissa Hoffmann

Larissa completed her studies in nutritional science in 2009 and graduated with majors in nutritional medicine. Thereafter, she started her career in the field of clinical trials as a study coordinator for regulated clinical trials in an in-patient clinical setting. After several years she took up a position as a clinical operations manager in a biopharmaceutical start-up company gearing towards the development of immune evasion vaccines and later joined Hipp GmbH & Co. KG as a clinical project manager for the management of clinical studies on infant formulas. During those years she completed several trainings in ICH-GCP, study management and medical writing. In 2018, Larissa joined the Division of Infectious Diseases and Tropical Medicine at the LMU Munich and acts as a clinical project manager for PanACEA TB trials in the office in Munich and in the field.

Rob Aarnoutse PharmD PhD

Rob Aarnoutse, PharmD PhD, is Associate Professor, hospital pharmacist and clinical pharmacologist, working at the Department of Pharmacy and with the Radboud Institute for Health Sciences at Radboudumc.

His research is focused on drug treatment of tuberculosis (TB), HIV and TB/HIV co-infection, the leading infectious disease killers worldwide. The central concept in his work is that efficacy and toxicity of drugs are dependent on drug concentrations achieved either systemically or locally. His research portfolio reaches from molecular pharmacological research to murine pharmacological studies, to pharmacokinetic studies in humans and clinical trials. In this way he develops a comprehensive translational research line that allows for quick application of relevant findings in the clinical setting. Typical topics of interest are adherence, pharmacokinetics, pharmacodynamics, safety/tolerability and effectiveness of TB drugs, antiretrovirals, other anti-infective drugs and immunosuppressants. His research is performed in The Netherlands, Indonesia, Tanzania, South Africa and other countries.

Rob Aarnoutse headed the Pharmacokinetic & Therapeutic Drug Monitoring Laboratory at Radboudumc for several years, is deputy director of education in hospital pharmacy for Radboudumc and is member of the Ethical Review Board Arnhem/Nijmegen. He has  been active in various national boards for the Dutch Society of Hospital Pharmacists (NVZA) and for SKML. He is member of the Coordinating and Executive Group of the Pan African Consortium for the Evaluation of Antituberculosis Antibiotics (PanACEA), is the chairman of the annual International Workshop on Clinical Pharmacology of Tuberculosis Drugs, and is otherwise well embedded in national and international gremia relevant to translational pharmacological research in the field of infectious diseases.

Dr. Francis Mhimbira

Dr. Francis Mhimbira is an epidemiologist and a TB clinical research scientist at Ifakara Health Institute (IHI, www.ihi.or.tz). He is the head of Interventions and Clinical Trials department at IHI. He has worked at Kibong’oto National TB Hospital in Tanzania (2006-2011) where he gained clinical experience on managing TB and TB/HIV co-infected patients. He joined IHI (2012-to date) and has been working in the TB research as a clinical research coordinator and investigator in a number of clinical trials, TB diagnostic studies and epidemiological studies on TB and co-infections in particular HIV and helminth infections. He was the site investigator for HIGH-RIF, NC-002, NC-005 and STAND TB drugs clinical trials. He also works with the Tanzania National TB and Leprosy Programme as a technical advisor to the TB Operational Research and Programmatic Management of Drug Resistant Tuberculosis Technical Working Groups.

Dr. Francis received his medical degree from University of Dar es Salaam, Tanzania, a Masters’ degree in Epidemiology from University of Melbourne, Australia and a PhD in Epidemiology from University of Basel, Switzerland.


Dr. Elin Svensson

Elin Svensson is a postdoctoral researcher at Radboud university medical center, focusing on pharmacokinetic and pharmacodynamic population modeling of clinical trial data. Elin holds a MSc in chemical engineering, and a PhD in pharmacometrics, both from Uppsala University, Sweden. The topic of her doctoral thesis was modeling of drug-drug interactions and exposure-response relationships for novel anti-tuberculosis drugs, partly within the PreDiCT-TB consortium. Elin also maintains a part-time researcher position at Uppsala University, and a close collaboration with the University of Cape Town, South Africa. She is part of several study protocol teams within the IMPAACT network, and is a member of the WHO Task force on PK/PD of tuberculosis medicines. Elin’s role in PanACEA includes study design and data analysis, primarily addressing questions regarding exposure-response relationships, dose optimization and biomarkers.

Olinde Hermans

Olinde is a research assistant in the PanACEA coordinating team at the Radboud University Medical Centre in Nijmegen, the Netherlands. She is responsible for the PanACEA secretariat and communication. She supports the management team with consortium and trial coordination. Olinde has a BA in Cultural Anthropology and Development studies and is currently finishing the master Political Theory, a specialization in Political Science at the Radboud University. Before her activities in PanACEA Olinde gained experience in study related boards and committees, services and administration.

Rutger Spoor MSc

In 2006 Rutger completed his studies in Business Administration at the Radboud University in Nijmegen, and graduated with majors in Strategic Human Resource Management. In 2006 he started working at PwC accountants as financial auditor mainly for SME’s and in Healthcare. At the same time he started his study in Auditing at the Vrije University in Amsterdam.  In 2009 he started working for the Radboud University Medical Center as Senior Projectcontroller and Teamleader for the department of Finance. He helped Principal Investigators and researchers at various departments managing their projects.  In this role he started in 2012 supporting the PanACEA I project. He helped with budgeting, financial reporting and auditing the financial reports from partners. In March 2017 he started working as project manager on PanACEA-II, focusing on consortium coordination, legal en financial.