SimpliciTB is a multi-centre phase 3 clinical trial evaluating a new shorter drug regimen (all-oral BPaMZ) in drug susceptible and resistant pulmonary tuberculosis across 4 continents led by TB Alliance. The trial started in 2018 and the European and Developing Countries Clinical Trials Partnership (EDCTP) has recently awarded 12 million euro for the execution of the…
On 19 and 20 March 2019 hosting partner Instituto Nacional de Saúde welcomed the General Assembly to Maputo, Mozambique, for the second PanACEA II Annual Meeting. Highlights of the second year of the PanACEA II programme were the completion of the HR1 trial, start of the postgraduate programme, site assessment visits and capacity development activities (e.g.…
In the quarterly teleconference on 10 December 2018 the PanACEA partners assembled to discuss the progress of the projects program. We looked back to 2018 as a year in which we ended our first trial. We are ready to start 2019, when our other trials are scheduled to start. The General Assembly meets again, face…
The Union World Conference served as a good occasion several PanACEA get togethers. On the 25th of October the Executive Group came together to discuss the completion of the HR1 trial and the preparations for the upcoming trials. The TBA was also invited to prepare for the SimpliciTB trial for which EDCTP favourably evaluated a grant application…
One of the yearly highlights in TB research is the Union World Conference. The 49th edition was hosted by the city of The Hague and the KNCV Tuberculosis Foundation from 24th until 27th of October 2018. This gathering of clinicians, public health workers, policy makers, researchers and advocates serves as an unique platform for a global public health…
The 11th International Workshop on Pharmacology on Tuberculosis Drugs was held in The Hague on 23rd of October 2018 during the week of the Union World Conference. At this premier TB pharmacology meeting leading experts presented and discussed the latest findings in the TB research. PanACEA was well represented by a delegation existing of Rob Aarnoutse (Radboudumc),…
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In the beginning of October the PanACEA Coordinator Martin Boeree travelled to Tanzania, Uganda and Gabon to continue the last site assessments of 2018, accompanied by lab coordinator Lavinia Rodney and project managers Lindsey te Brake and Rutger Spoor. We were happy to see the study teams of IHI, NIMR MMRC, KCRI (Tanzania), MML (Uganda)…
At the annual INTERTB meeting on October 22nd 2018 in London PanACEA Coordinator Martin Boeree and other renown experts on TB clinical drug development came together to discuss the research developments in the field. The 50 mg/kg rifampicin arm in the HR1 trial is completed and Martin Boeree lifted the veil on the preliminary results. We…
In the beautiful city of Lisbon, Portugal, the EDCTP held its Ninth Forum, an international platform for the presentation and discussion of frontier research to address the burden of poverty related infectious diseases in Sub-Saharan Africa. The theme of this Forum was the impact of European-African partnerships in clinical research, which is at the heart…
Every 3 months the PanACEA consortium is meeting via teleconference to update each other on the progress of the trials and the capacity development program. On September the 10th 2018 the partners assembled again. The so-called Expertise Cores can finally carry out their plans. They have started to purchase data management systems and statistical software. The PanACEA…
