PanACEA-SUDOCU-01 publication in the Lancet Infectious Diseases 08 July 2025

PanACEA-SUDOCU-01 was a phase 2b clinical trial conducted at four locations in Tanzania and South Africa. The innovative study design allowed administration of a novel backbone of bedaquiline–delamanid–moxifloxacin alone and together with four sutezolid doses (ranging from 600 mg once daily to 800 mg twice daily) to 75 adults with drug-susceptible pulmonary tuberculosis for 12…

Podcast on TB drug development with Lilian Tina Minja and Norbert Heinrich for the Lancet

The Lancet Infectious Diseases in conversation with Lilian Tina Minja and Norbert Heinrich on TB drug development Lilian Tina Minja and Norbert Heinrich discuss the SUDUCO and DECODE trials in The Lancet Infectious Diseases on two new promising TB drugs, sutezolid and delpazolid, respectively. They also discuss the wider implications of the findings of these trials for…

Staggered dosing of rifampicin using to minimise tolerability problems and maximize efficacy

PanACEA team together with collaborators at Uppsala University recently published a model-based study further elucidating how to optimally dose rifampicin. The work suggest that a staggered approach, starting a bit lower and then increasing doses, may improve the tolerability for patients and thereby enable the higher doses which we demonstrated earlier is beneficial in terms…

SUDOCU headline results presented at CROI

On Tuesday 20 February 2023 our PanACEA colleague Dr Norbert Heinrich presented the headline-results from the PanACEA SUDOCU study at the 30th Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle – the largest and most important conference on HIV and related conditions such as tuberculosis. SUDOCU investigated safety and efficacy of varying doses of…

PanACEA & SimpliciTB Annual Meeting, Mangochi, Malawi, 20th-22nd September 2022

Finally, after 2 years due to COVID-19, the PanACEA and SimpliciTB family were reunited in Malawi, hosted by Dr Marriott Nliwasa, Kamuzu University of Health Sciences at Makokola Retreat, Mangochi. The hospitality and organisation of all of the teams made it a very successful and enjoyable meeting. PanACEA The first day started with a variety…

STATUS update: SUDOCU completed recruitment!

The PanACEA SUDOCU study completed its recruitment: a total of 75 participants were randomized to 5 arms (15 participants each) with a wide range of sutezolid doses (from 0mg to 800mg BID given over three months). With this open-label, randomized, phase 2B, dose selection study (ClinicalTrials.gov identifier NCT03959566) we aim to describe the safety/tolerability-exposure relationship…

Shorter treatment may be possible with higher rifampicin doses

An interview with prof. dr. Martin Boeree A considerably higher dose of the anti-tuberculosis drug rifampicin has been found to be safe according to a recent publication by PanACEA. Higher dosing of rifampicin may lead to a shorter / more efficacious treatment for tuberculosis with less resistance development. With this finding PanACEA researchers complete a…

Can Calculus Help Tuberculosis Treatment?

The St Andrews group’s most recent paper has been published as a perspective piece in the International Journal of Tuberculosis and Lung Disease.The collaboration between the Schools of Medicine, Applied Mathematics and Computer Science provides an overview of the different types of model that can be applied to tuberculosis clinical trials. Importantly, it provides a…

Community engagement workshop

In the afternoon of 20th of February a ninety minutes interactive workshop on community engagement was held. The inspiring Erica Sanga, Community Engagement Coordinator at NIMR Mwanza, Tanzania, led the workshop. During this workshop, participants from different sites shared their experiences and challenges on community engagement activities. Participants discussed their best practices for successful engagement…

SimpliciTB General Assembly F2F

Delegates from all of our collaborators in SimpliciTB TB travelled from across the world to attend the annual face to face General Assembly (GA) meeting in Mbeya, Tanzania. Trial progress was reported, with a focus on recruitment and medical monitoring. An important development was the launch of the Capacity Development programme that allows members of…