Dr. Marriott Nliwasa

Dr Marriott Nliwasa is a final year PhD student with the London School of Hygiene and Tropical Medicine. His PhD covers strategies to reduce risk of early death among adults with symptoms suggestive of tuberculosis (TB): i.e. increasing access to HIV testing, TB screening in communities and health facilities, evaluation of new TB diagnostic tests (Xpert MTB/RIF and TB-LAMP) and their impact on patient outcomes. Marriott’s immediate future research focuses on trials of other new TB tests including Xpert MTB/RIF Ultra, digital chest radiography, IRISA-TB (for TB meningitis). Marriott is also involved in trials of new TB drugs and new TB drug regimens under the EU-Africa PanACEA consortium.

 

Sébastien Gagneux PhD

Sébastien Gagneux is Associate Professor of Infection Biology and Head of Department at the Swiss Tropical and Public Health Institute (Swiss TPH)/University of Basel. After receiving his PhD from the University of Basel, he worked as a postdoctoral fellow at Stanford University and at the Institute for Systems Biology in Seattle, USA. He then spent three years as a Program Leader at the MRC National Institute for Medical Research in London, UK before joining Swiss TPH. His research focuses on the ecology and evolution of Mycobacterium tuberculosis, and combines population genomics, molecular epidemiology and experimental approaches to study the effect of bacterial variation on host-pathogen interaction and drug resistance.

 

Dr. Blandina Theophil Mmbaga

Blandina Theophil Mmbaga is a Director of Kilimanjaro Clinical Research Institute at Kilimanjaro Christian Medical Centre in Moshi, Tanzania since 2015 and a Director of the KCMC-Duke University Collaboration Clinical Research site in Moshi since 2013. She also works as a pediatrician at KCMC, Senior Lecturer Kilimanjaro Christian Medical University College (KCMUCo) and Adjunct Ass. Professor of Duke Global Health Institute. Blandina had her undergraduate done at the Nizhny Novgorod State Medical Academy in Russia and Pediatric residence at KCMUCo, Tumaini University. She had her doctorate in public health and epidemiology at the University of Bergen in Norway. She is leading several research activities at KCMC and KCRI mainly in infectious diseases (Tuberculosis, HIV/AIDS, Antimicrobial resistant and zoonoses diseases) as well as maternal and child health.

Blandina has a good experience in leading clinical trials in HIV/AIDS and Tuberculosis under her leadership as IMPAACT scientific and immunology committee member 2006-2012 and IMPAACT site PI since 2013 to date. She has a good experience in students supervision and mentorship both masters and PhD levels within KCMUCo and outside Tanzania (UCT, Glasgow, Bergen University, London School and Duke University) as part co supervision within collaborative research capacity building.

Dr. Mohammed Siddique Rassool

Dr Rassool is a project investigator and project manager for the PanACEA project  at the Clinical HIV Research Unit, University of the Witwatersrand Helen Joseph Site.

Dr Rassool holds a medical degree (MBChB) and a diploma in HIV management. He has a long-standing ten year experience in phase II-IV clinical trials.  Over the past seven years, Dr Rassool has been managing various projects.  He also provides technical and advisory support to the local clinics in the Johannesburg region. He is also lectures medical doctors who attend HIV management courses.

Furthermore, Dr Rassool’s main areas of research are HIV, TB, HIV and TB co-infection as well as other HIV related co-infections (including Kaposi Sarcoma and Hepatitis B). He has 10 publications dealing with HIV and associated conditions.

Dr. Nyanda Elias Ntinginya

Nyanda Elias Ntinginya is a leader in all TB studies at NIMR Mbeya Medical Research Centre (NIMR-MMRC) www.nimr-mmrc.org  since 2012 and from July 2016 he was appointed the Ag. Centre Director of the same centre. He is the Principal Investigator of PanACEA related studies at NIMR Mbeya Medical Research Centre and therefore oversees activities related to all research initiation, implementation,  and coordination at the site.

He is the Medical Doctor and holder of a Master Degree in Tropical and Infectious Diseases from the Liverpool School of Tropical Medicine UK. Recently, Nyanda has successfully defended his PhD at the CIHLMU Centre for International Health at Ludwig-Maximilians- Universität, Munich; Germany. Nyanda has more than 8 years of experience in managing clinical trials, diagnostic and operational studies as a Coordinator, Principal Investigator, Clinical Trial Manager at institutional and national levels in cross-functional and multicultural and international environment. A recognizable experience in research of TB new drugs and diagnostic as well as emerging diseases with a strong expertise on ICH GCP guidelines.

Furthermore, his main area of research interest is on Infectious Diseases in particular TB; ranging from diagnostics, therapeutic to operational/implementation research. He has published particularly with TB, HIV and selected other infectious diseases.

Prof. Timothy McHugh

Tim McHugh’s work focuses on respiratory disease with particular emphasis on tuberculosis, with projects that cover the spectrum of activity from transcriptomic analysis of responses to drug treatment through to clinical and operational research in hard to reach communities. The Centre contributes at each end of the anti-tuberculosis drug development pipeline; at one end screening novel compounds for activity and exploring the mechanism of action whilst at the other end of the pipeline providing expertise and infrastructure for the delivery of TB treatment trials. A key element of this work is supporting the development of appropriate laboratory facilities for the handing of high risk pathogens. An important element of his work is capacity development, the Centre provides training for laboratory scientists both on site and in London.

Dr. Norbert Heinrich

Dr Norbert Heinrich is a board certified paediatrician, who has field work experience in Mchinji District, Malawi. He joined University of Munich in 2008, when the PanACEA consortium was starting up, to become a senior scientist in tuberculosis treatment and diagnostic studies. He acted as sponsor medical expert for the SQ109 EBA and the PanACEA MAMS TB 01 study, and is now coordinating LMU’s team in the PanACEA studies, but also in the AIDA study to validate new diagnostics, under the leadership of Prof. Michael Hölscher. In addition to TB, Dr Heinrich is pursuing research in the field of febrile illness, within the German Center for Infection Research; maintaining the strong partnership that exists between the NIMR-Mbeya Medical Research Centre, and LMU within these networks. To support career development of African scientists in joint projects, Dr Heinrich supervised four PhD students to successful graduation to date.

Prof. Ian Matthias Sanne

Prof. Ian Matthias Sanne is a native South African and HIV Clinical Researcher who recently was elected as International Vice-Chair of the AIDS Clinical Trials Group. His research focuses on providing observational and prospective research to inform prevention and treatment strategies in HIV and TB in resource poor settings, with scientific contributions to the optimization of treatment strategies, improved diagnostics and public health interventions for HIV and Tuberculosis leading to over 100 publications. At the intersection of clinical care and clinical trial administration, will offer his expertise from his experience as the founding Director and Chief Executive Officer of Right to Care, a large PEPFAR and Global Fund supported non-profit organization. He has served in a number of leadership roles, both in research and implementation of clinical treatment services. Since 2003, he led the Wits HIV Research Group as CTU Principal Investigator.

Dr. Klaus Reither

Klaus Reither is working as the Head of the Clinical Research Unit and Group Leader ‘Clinical TB Research’ at the Swiss Tropical and Public Health Institute. His responsibilities comprise set-up, implementation, coordination and supervision of clinical research projects with emphasis on TB clinical trials at international partner institutes of Swiss TPH, particularly at the Ifakara Health Institute in Tanzania. From 2009 to 2013, Klaus Reither was working as the TB Team Leader at the Ifakara Health Institute; employed by Swiss TPH. In this time he was in charge of building up a clinical TB trial site and performing trials on TB epidemiology and immunology, new vaccines and new treatment regimens as well as new TB diagnostic. Prior to this position, Klaus Reither managed TB projects in Mbeya, and mainly malaria studies in Tamale, Ghana for the Universities of Munich and Berlin, Germany. Klaus Reither received his medical degree from the Free University Berlin, earned an academic MD title at the German Heart Centre Berlin, pursued an MSc in International Health and a Diploma in Tropical Medicine and Public Health from the Humboldt University Berlin and completed a PhD in Epidemiology at the University of Basel. He has clinical experience in internal medicine and is a specialist in diagnostic radiology.

 

Dr. Patrick Phillips

The objective of Dr. Philips’ research continues to be to design, implement, and optimize clinical trials for new treatments for tuberculosis in order to deliver safer and more efficacious regimens for patients. A key focus of his research has been to improve the design of TB clinical trials through implementation of novel methodology so that regimen development is faster and more efficient. This was motivated by his PhD thesis evaluating surrogate endpoints for TB trials, and has grown in a number of areas through the various collaborations and consortia that he contributes to.

Dr. Philips joined the Division of Pulmonology in July 2017 and previously was senior statistician at the MRC Clinical Trials Unit at UCL in London. He has worked on late-phase clinical trials in tuberculosis for more than a decade, most recently as trial statistician in the REMoxTB and RIFAQUIN phase III trials. He leads the statistics core of the African/European PanACEA consortium evaluating novel regimens for the treatment of TB, designing the PanACEA MAMS-TB phase II trial with a Multi-Arm Multi-Stage (MAMS) design. He is lead statistician for the USAID-funded STREAM Stage 1 trial evaluating the new 9-month MDR-TB regimen. Ongoing methodological areas of interest include the evaluation and use of surrogate endpoints, the conduct and analysis of non-inferiority trials and trial design with a focus on adaptive designs. He is an associate editor for the journal Trials.